PHYSIOLOGY AND PATHOPHYSIOLOGY OF PROTEINASE-ACTIVATED RECEPTORS (PARS): PAR-2 AS A POTENTIAL THERAPEUTIC TARGET

Physiology and Pathophysiology of Proteinase-Activated Receptors (PARs): PAR-2 as a Potential Therapeutic Target

PAR-2 mcdsp apb 8 is the second member of the family of proteinase-activated receptors activated by trypsin, tryptase, and several other serine proteinases.In order to evaluate the therapeutic potential for PAR-2, we have performed studies on PAR-2-mediated signal transduction and investigated the effects of PAR-2 gene deficiency in disease models.

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Forced finite-time barotropic instability

The finite-time barotropic instability problem is modified by investigating the impact of an anomalous (steady) forcing on the development of optimal initial perturbations.Although the model considered is linear, due to the nonlinear optimization procedure the addition of a forcing can influence the initial disturbance.In particular, a quasi-geostr

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Applying the Operational Design Domain Concept to Vehicles Equipped with Advanced Driver Assistance Systems for Enhanced Safety

Advanced driver assistance systems (ADASs) assist drivers by alerting them of the occurrence of events based on the sensing capabilities of the vehicle, reducing the effort required by drivers.Most vehicles that are recently launched vehicles have been endowed with ADAS, thereby significantly reducing traffic accidents.However, the Insurance Instit

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